Jennifer Weiner’s books can be counted on for memorable characters, intricate relationships, and terrific story arcs. The Griffin Sisters’ Greatest Hits delivers all of these.

In this 2025 novel, we’re transported back to the music scene of the early aughts and the rise of the Griffin Sisters, a band whose one album changed lives. Even twenty years after their sudden breakup, devoted fans still love them, and the use of their music in a popular new Netflix series has brought them back into the spotlight once more.

But who are the Griffin Sisters, and where did they go?

As we learn, Cassie and Zoe Griffin were born Cassie and Zoe Grossberg, the daughters of a young, working class Philadelphia couple. Zoe — full of beauty and sparkle — is a delight from birth, but the surprise pregnancy that brings Cassie along less than a year later is not a welcome development for their parents. Their mother struggles to love Cassie the way she loves Zoe, and Cassie’s differences confuse and frustrate her parents.

Everything changes when a preschool teacher notes Cassie’s uncanny musical ability. Although still basically a toddler, Cassie can play the piano by ear, and has a remarkable singing voice as well — although she’s so silent and withdrawn that she’ll only sing with Zoe. And so it goes: Zoe is pretty and popular, and protects Cassie (when she can) from the crueler comments directed at her by other children. Cassie is large, awkward, unsocial, and doesn’t care about clothes, entertainment, or making friends. Music is her only passion, and eventually, she enrolls in a music school in order to pursue a career as a classical pianist.

But Zoe craves the spotlight and stardom. Her perkiness puts her at center stage, even though her singing voice is passable at best. Her knowledge of music is limited to Britney and Cristina and the Spice Girls. She yearns to be a pop princess — and when her bandmates kick her out right before a Battle of the Bands competition, she begs Cassie to perform with her instead. Cassie has no interest, hates being seen, and just wants to be left alone… but she can’t let her sister down. In their performance, Cassie’s gift shines — her voice is transcendent, and while Zoe is the visual appeal, it’s Cassie’s singing and playing that makes their time on stage magical.

So magical, in fact, that a talent agent rushes to their house the next day and whisks them off to a recording label’s headquarters in New York. In the blink of an eye, the teen sisters are signed to a contract and are being prepped for a cross-country tour of radio stations and small venues. To turn the Griffin Sisters in a hit-machine, they need a songwriter, and Russell D’Angelo enters their lives. In his mid-twenties, Russell has a former band, is a talented guitar player, and a genius for writing songs. He and Cassie immediately click and begin creating together, but Zoe is interested in Russell for entirely different reasons. Once he joins the band, it’s only a matter of time before things get complicated.

We know from the opening pages of The Griffin Sisters’ Greatest Hits — the one chapter told from Russell’s point of view — that something terrible happens to tear the band apart at the height of their success. As the book progresses, chapters focused on the band’s rise are interspersed with chapters set in 2024, through which we see just how differently Zoe and Cassie live twenty years later.

In 2024, two decades past their peak stardom, Zoe is a suburban housewife and mother. Yes, she still gets recognized as Zoe Griffin, but those days are long behind her. Zoe’s 18-year-old daughter Cherry has a musical gift of her own and yearns to pursue her own musical career, but Zoe blocks her at every turn, cautioning her about the cruelty of the music industry toward young women.

Meanwhile, Cassie has fled just about as far as she can go — no one has seen her in these past twenty years. She lives alone in Alaska on private acreage, hiding from the world, venturing out as little as possible, and denying herself anything that would give her pleasure, including music.

It takes a good 75% of the book to unravel the mystery of what happened to the Griffin Sisters and explain how Zoe and Cassie ended up with the lives they have now. Thanks to the author’s skillful development of the characters and their complex relationships, there’s never a dull moment as she weaves together the past and present timelines. By the time we get to the answers, we understand deeply both what happened and why, how each character perceived or misunderstood the key events, and how this affected their lives from that point forward.

I’m sure people will compare this lovely novel to Daisy Jones and The Six (a book that I love) — and yes, there are some similarities: A wildly popular band falling apart after only one album together, with plenty of “where are they now?” speculation. But, while the music industry pressures and excesses may feel familiar at times, the stories are quite different. Here, the beating heart of the story is the relationship between Cassie and Zoe, as well as the shifting, new dynamic that occurs once Zoe’s daughter Cherry makes it her mission to reunite the sisters (and the Sisters).

Cassie and Zoe are both flawed but fascinating characters. I’ll admit that it’s very hard to like Zoe, and she behaves terribly in many, many situations, often causing horrible damage. Still, the author is careful to make sure that readers understand Zoe — and while we may hate much of what she does, we also understand the fears and insecurities that drive her actions.

The audiobook, narrated by Dakota Fanning, is a joy to listen to. While on the lengthy side, it’s so well told that I never felt impatient or frustrated. The narration captures the characters’ personalities very well — they feel distinct and recognizable throughout.

I had only two minor quibbles by the end of the book. First, there a moment — very late in the story — where Zoe raises the issue of whether Cassie might be on the neurodivergent spectrum — and honestly, that felt a bit out of the blue. Yes, Cassie has a great deal of difficulty in social and public settings, but I never had a sense that she might be considered neurodivergent. I felt that if that was the case the author wished to make, there needed to be a lot more breadcrumbs throughout the book to support this.

My other quibble has to do with a plot thread left dangling at the conclusion:

Highlight the black area to reveal text — ONLY if you don’t mind a spoiler: Who is Cherry’s father? Zoe admits that she’s not sure — it could be Russell, but it could also be Tommy, the band’s drummer. As the story wraps up, I expected some sort of resolution, or maybe even just a hint that Zoe and Cherry might reach out to Tommy… but the matter just isn’t addressed again.

This issue is not critical to the overall story, which — big picture — is about Zoe and Cassie and whether they can find their way back to one another — but it still annoyed me at the end not to get an answer to this particular question.